Pomegranate Extract(Punicalagins) and benefits,side effect, uses,dosage | Natural Antioxidant

Punicalagin is an ellagitannin found in the fruit peel of Punica granatum. We have demonstrated antioxidant and antigenotoxic properties of Punica granatum and showed that PC and ellagic acid  are its major constituents.Punicalagin is the polyphenol with the highest molecular weight discovered up to now. It is hydrolysed in ellagic acid and has the highest antioxidant capacity in the pomegranate.

What you may get from us: If you're developing a product that contains plant active ingredients from Pomegranate Extract.I think you can find the information or products you need here.

Simple production process in our factory: After the plant is collected, raw material will be processed by solvent extraction, separation and purification, filtration, concentration, drying and other steps to form the final products. We may also design a prouction process based on your special requirements.

Through the physical and chemical processes, those compunds you don't want was removed, and the compunds preferred was accumulated. Which make the products achieve the best effects.  

How to use Pomegranarte extract powder: What you need is just use our products to formulate your products. It can be mixed with your other ingredients directly to make premix products. It can also be directly used for filling capsules or making tablets. And if your dosage form is tincture or solution, It can also be suitable. Easy to say, our products are ready for Formula products.
 

General Information

Latin Names:Punica granatum, Punicaceae

Other Name: 2, 3-(S)-hexahydroxydipehnoyl-4, 6-(S, S)-gallagyl-D-glucose

Plant Description
Pomegranate: The pomegranate (Punica granatum, Punicaceae)is an attractive  tree  that grows up  to 5 m  in height. It has glossy, leathery leaves and bears showy red f lowers at the branch tips. Thedistinctive shape of the spherical fruit (2.5 to 5 inches in diameter)is imparted by the prominent f leshy red calyx which persists after flowering.  The  fruit  has  a  tough  leathery  skin  that  is  variously referred to as the rind, husk, or pericarp. The  interior of the fruit is compartmentalized  by membranous  walls  (carpels)  and  white spongy pith. The resulting locules are packed with 600 to 800 sacs or arils, each of which contains one seed and juicy pulp. Conventional  pomegranate  juices  normally  constitute  45  to  65%  of  the whole fruit.

Definition:

Punicalagins are tannins, large polyphenol compounds which are isomers of 2,3-(S)-hexahydroxydiphenoyl-4,6-(S,S)-gallagyl-D-glucose, hydrolysable tannins with a molecular weight of 1084. They are found in forms alpha and beta in pomegranates. Punicalagins are water soluble and have high bioavailability. They are known to hydrolyze into smaller polyphenols such as ellagic acid in vivo where one potential mechanism is hydrolysis across the mitochondrial membrane of cultured human colon cells.

Punicalagins is extracted from pomegranate fruit, The purity is range from 20% to 40%.


Health Benefits of Punicalagins

Potential Aspects of Punicalagins:

Punicalagins are shown to benefit the heart and blood vessels. Punicalagias are the major component responsible for pomegranate's antioxidant and health benefits. They not only lower cholesterol but also lower blood pressure and increase the speed at which heart blockages (atherosclerosis) melt away. Recent medical research studied heart patients with severe carotid artery blockages. They were given an ounce of pomegranate juice each day for a year. Not only did study participants blood pressure lower by over 20%, but also there was a 30% reduction in atherosclerotic plaque. Just as astounding, participants who did not take the pomegranate juice saw their atherosclerotic plaque increase by 9%. In other studies, potent antioxidant compounds found in pomegranates have shown to reduce platelet aggregation and naturally lower blood pressure, factors that prevent both heart attacks and strokes. Not only are pomegranates good for heart and blood vessels but also they have been shown to inhibit breast cancer, prostate cancer, colon cancer, leukemia and to prevent vascular changes that promote tumor growth in lab animals, Several in vitro studies have shown this remarkable anti-cancer effect. Additional studies and clinical trials currently taking place are hopeful to reveal this fascinating effect on humans. Also of note, pomegranate juice contains phytochemical compounds that stimulate serotonin and estrogen receptors, improving symptoms of depression and increasing bone mass in lab animals. It is recommendable that all patients who have heart disease, high cholesterol, or high blood pressure as well as those who are looking to prevent these ailments incorporate the powerful components of pomegranates into their diet. Pomegranate extracts standardized for their primary active component, punicalagins, have received considerable attention for their role cardiovascular protection, weight management and cancer prevention. Punicalagins are the most important active component in the fresh pomegranate fruit; these are typically lost or in very low amounts when pomegranate juice is made. A new study shows that punicalagins have potent anti-fungal activity against Candida Albicans.

Pharmacological Activity

Antioxidant Activity:

The potent antioxidant capacity of pomegranate and its components has been reported by numerous scientists using multiple in vitro assay systems. This activity is largely due to the polyphenolic constituents. Punicalagins and other polyphenols in pomegranate have higher total polyphenolic content and greater antioxidant activity than other commonly consumed fruit juices, including grape, cranberry, orange and apple juice among others. Pomegranate punicalagins with other polyphenols were found to be potent antioxidant in protecting nitric oxide then Concord grape juice, blue berry juice, red wine, vitamin C and vitamin E .

Cardiovascular Health:

The primary health benefits of punicalagins have focused on the antioxidant actions and its potential to prevent atherosclerosis as well as slow progression of atherosclerotic plaques. Five small human clinical trials testing cardiovascular activities have evaluated punicalagins for effects on cholesterol, atherosclerosis, myocardial perfusion, hypertension and erectile dysfunction.

Prostate Cancer:

A well designed phase-II clinical study suggest that Punicalagins and other pomegranate tannins may be potentially effective in slowing progression of prostate cancer and reducing recurrence rates of the disease.

Precautions:

Punicalagins is considered generally safe, with no known side effects.