Genistein, also known as genistein, genistein, 5,7,4-trihydroxyisoflavone, is mainly from soybean, clover, pueraria, sophora japonica, sophora japonica, genistein (gorse flower) ) and the active ingredient extracted from leguminous plants such as broad bean root, is a natural tyrosine kinase and soybean substitute ten substances, known as phytoestrogens. Genistein is one of the isoflavones with the highest activity and function. It is a single component. It is a compound with weak estrogen-like effects and non-estrogenic compounds. It is widely used in pharmaceuticals, health care products and other fields.

Genistein effect

1. Anti-tumor: inhibits the growth of various tumor cells, can regulate genes related to cell proliferation and apoptosis; inhibits NF-κB and Akt signal transduction pathways; potentially inhibits angiogenesis and lesion metastasis, as well as enhances radiotherapy and chemotherapy. Sensitivity.

2. Antioxidant

3. Prevention of cardiovascular and cerebrovascular diseases: promote blood lipid metabolism, prevent lipid oxidation, soften blood vessels

4. Prevention of osteoporosis: It can promote the proliferation, differentiation and bone formation of bone cells; inhibit the proliferation, differentiation and bone resorption of osteoclasts.

5. Protect nerve cells: It can affect the morphological structure of the brain through the blood-brain barrier, improve brain function, and prevent Alzheimer's disease.

6. Weak estrogen-like effect: Genistein, as a natural phytoestrogen recognized internationally, has a structure similar to estrogen, and has a preventive effect on menopausal symptoms.

7. Others: anti-inflammatory, analgesic, uric acid lowering

8. Anti-osteoporosis

As a "phytoestrogen", genistein can promote the proliferation, differentiation and mineralized bone formation of osteoblasts, and can also inhibit the bone resorption process of osteoclasts. There are various molecular mechanisms against osteoporosis.

The anti-osteoporosis effect of genistein involves mechanisms such as promoting the proliferation, differentiation and bone formation of osteoblasts, and inhibiting the proliferation, differentiation and bone resorption of osteoclasts. In addition, as a "phytoestrogen", genistein binds to estrogen receptors (ER) in vivo to produce a positive regulatory effect, which is an ideal selective estrogen receptor regulatory activity. of natural compounds.

Genistein can inhibit osteoclast bone resorption through the NF-κB pathway. In addition, genistein can mediate intracellular calcium ion signaling pathway and inhibit protein kinase and tyrosine kinase, thereby causing osteoclast apoptosis and inhibiting bone resorption. Osteoclast formation can also be reduced by inhibiting the activity of DNA topoisomerase II.

Osteoporosis is a disease with increasing morbidity and disability rate. Therefore, new anti-osteoporosis drugs have always been a research hotspot at home and abroad. As a safe and effective "phytoestrogen", genistein can selectively bind to ER in the body and play a role in preventing and treating osteoporosis. In addition, genistein is rich in sources and simple in extraction process, which is beneficial to industrial production, and has less toxic and side effects in the long-term treatment process, and has good clinical application prospects.

9. The estrogen-like effect of genistein

As a "phytoestrogen", genistein is structurally similar to endogenous estrogens (such as 17β-Estradiol) and has estrogen-like effects. In the human body, there are two types of estrogen receptors, estrogen receptor ɑ (REɑ) and estrogen receptor beta (REβ). In addition to the reproductive system, ER exists on osteoblasts, osteoclasts, and bone marrow stromal cells. Among them, ERɑ is mainly expressed in skeletal osteocytes, and ERβ is very lowly expressed in skeletal osteocytes; ERβ is significantly expressed in cancellous osteocytes, and is also expressed in the nucleus and cytoplasm of osteoclasts. The affinity of genistein to ERβ is greater than that of ERα, but the main receptor for its anti-osteoporosis effect is ERα, so ERα is the main receptor subtype of genistein for bone protection. In addition, phytoestrogens bind to ER in vivo and have a bidirectional regulatory effect, that is, they exhibit estrogen-like or anti-estrogenic effects (low concentration promotion, high concentration inhibition) under different conditions, which is an ideal estrogen replacement drug.

Application of Genistein

1. Jinzhuanting Capsule is a capsule product developed and produced with natural isoflavone extract as raw material and advanced technology. Its main functional ingredient is Genistein. It has been confirmed by functional tests that this product can assist in inhibiting tumors. growth transfer. Jinzhuanting Capsule is superior to previous chemical drugs and Chinese herbal medicine due to its unique mechanism, exact curative effect, no toxic side effects, and pure natural characteristics. Health is important. Since the product was put on the market, it has sold well all over the country, and has attracted customers from Japan, the United States, Canada, Hong Kong and Southeast Asia, showing a broad market prospect.

2. Source Naturals women's genistein powder, rich in genistein, delays aging.

3. i-cool menopause bone health chewable tablets, the main ingredients (vitamin D, calcium, genistein). It is used to promote bone growth and development and prevent osteoporosis.

Genistein for sale

1. Nutra Herb Ingredients Co., Ltd. has been focusing on the production of genistein for decades, and has controlled the quality and stability of raw materials from the source. From the admission of raw materials to the final product, we strictly follow GMP requirements to ensure product quality.

2. The company has advanced imported testing equipment to ensure traceability testing of each link from raw materials to production.

3. Professional technical team, strictly control the quality and quality.

4. The product has no pesticide residue, low solvent residue and high purity.

If you need genistein, you can contact us by email: Sales@nutranerbsource.com.

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