Introduction to Ursolic Acid

Ursolic acid is distributed in about 7 families and 46 genera and 62 species of plants in the form of free form or combined with sugar to form glycosides. Mainly are privet leaves of Oleaceae, bearberry of Rhododendron, loquat leaves of Rosaceae, leaves of Paulownia tomentosa of Scrophulariaceae, whole grass of Prunella vulgaris of Lamiaceae, leaves of holly of holly, etc. .

The study found that ursolic acid can significantly inhibit the proliferation of HL-60 cells and induce their apoptosis; it can significantly improve the phagocytic function of macrophages in mice. In vivo experiments have shown that ursolic acid can significantly enhance the immune function of the body. It shows that ursolic acid has a wide range of anti-tumor effects, and it is very likely to become a low-toxic and effective new anti-cancer drug.

The efficacy and role of ursolic acid

Ursolic acid is a triterpenoid compound present in natural plants. It has various biological effects such as sedation, anti-inflammatory, antibacterial, anti-diabetic, anti-ulcer, and lowering blood sugar. Ursolic acid also has obvious antioxidant function. , so it is widely used as raw materials for medicine and cosmetics.

1. Ursolic acid has the effect of protecting liver and anti-hepatitis

The clinical manifestations of ursolic acid have the effects of significantly and rapidly reducing alanine aminotransferase, serum aminotransferase, remission of jaundice, increasing appetite, anti-fibrosis and restoring liver function. It has the characteristics of quick effect, short course of treatment and stable effect.

Indian scholars and others found that pretreatment with ursolic acid could significantly improve the survival rate of rat hepatocytes, and in the experiment, it was observed that ursolic acid had an anti-cholestasis effect, and both bile flow and its contents were increased.

2. Ursolic acid has anti-tumor effect

Ursolic acid also has resistance to a variety of carcinogenic and cancer-promoting substances. In addition, ursolic acid also has preventive and inhibitory effects on various stages of tumor formation and growth, inhibiting tumor formation and growth and inducing cancer cell differentiation. Li J et al. have proved through experiments and clinical trials that ursolic acid can resist DNA mutation and inhibit the initiation of carcinogenesis, and that ursolic acid can resist carcinogens such as benzopyrene and aflatoxin Bl to induce gene mutation. Wang Peng test used early antibody (EBV-EA) activation test type to screen inhibitors of skin cancer carcinogens, and found that ursolic acid had almost the same inhibitory effect as retinoic acid on TPA-induced EBV-EA activation in Raji cells, and made it possible The survival rate of Raji cells is higher; the use of isotope-labeled phorate compound 3H-PDB2 proves that ursolic acid does not affect the binding of TPA to receptors, not by competing for TPA sites, but effectively blocking the binding of carcinogens to receptors The latter part comes into play. H ursolic acid ng et al found that ursolic acid can significantly inhibit the carcinogenic effect of TPA on dimethylbenzanthracene (DMBA)-induced mouse skin cancer, and the mechanism is that TPA can induce epidermal ornithine decarboxylase (ODC) The activity is enhanced, and ursolic acid can inhibit the above-mentioned links, thereby causing polyamine depletion, inhibiting growth, causing cells to accumulate at an early stage and differentiate.

3. Ursolic acid has antioxidant properties

Ursolic acid is a strong antioxidant. Experiments have shown that ursolic acid can inhibit the activities of 5-lipoxygenase and cyclooxygenase in the process of arachidonic acid metabolism, and prevent the production of prostaglandins and leukotrienes. Oxide causes. Subbaramaiah and other studies showed that ursolic acid can inhibit the transcription of cyclooxygenase in human mammary epithelial cells, thereby inhibiting the production of prostaglandins.

The antioxidant effect of ursolic acid has positive effects on the human body's anti-aging, skin freckle and pigment removal. Among the 29 patents on ursolic acid in Japan from 1983 to 2004, 10 are about the application of ursolic acid in skin beauty and health care. As a cosmetic, ursolic acid has stable properties, and its color and odor do not change with time. Good touch feeling, so it has a wide range of applications in beauty and skin care products.

4. Ursolic acid has antibacterial, anti-inflammatory and antiviral properties

Tapondjou et al. confirmed through acetic acid writhing test and hot plate method that ursolic acid and hydroxyursolic acid have similar anti-inflammatory and bacteriostatic effects. Ursolic acid can inhibit the production of superoxide induced by formylmethionyl-leucyl-phenylalanine (fMLP) and arachidonic acid, respectively. When ursolic acid and fMLP were added to cell culture medium, ursolic acid dose-dependently inhibited 45 ku protein tyrosine phosphorylation induced by fMLP. Ursolic acid also has trypanicidal activity, and after 2 h incubation at a concentration of 2 g•L, the activity of the trypanosoma cruzi flagella was completely inhibited.

Ursolic acid can cause a decrease in cell viability. Wang Peng proved that ursolic acid induces genomic DNA division, indicating that its mechanism of inducing cell death is through apoptosis. Ursolic acid can inhibit the proliferation of human acute promyelocytic leukemia cells (HL-60), and it can inhibit half of HL-60 cells. The inhibitory dose (IC50) of growth is 8.26 μm, and it can induce co-occurrence of apoptosis.

5. Ursolic acid has the effect of lowering blood lipid, anti-atherosclerosis and lowering blood sugar

Ursolic acid can reduce blood cholesterol (44%) and B-lipoprotein levels (50%) in rabbits and rats, and has hypolipidemic and anti-atherosclerotic effects. Ursolic acid can improve liver and kidney yin deficiency, tinnitus, dry mouth, less sleep, irritability, numbness and fear of cold, constipation caused by dyslipidemia. The total effective rate of blood lipids is 95%.

6. Ursolic acid has an inhibitory effect on HIV

Human immunodeficiency virus (HIV) is the causative agent of acquired immunodeficiency syndrome (AIDS). Tian Ying et al. have proved through clinical trials that ursolic acid has a strong inhibitory effect on HIV-1 protease activity, and its 50% inhibitory concentration (IC50) is 8 μmol/L. HIV-1 protease is a homodimeric enzyme, and ursolic acid may inhibit the activity of HIV-1 protease by inhibiting the dimerization of HIV-1 protease, thereby inhibiting HIV-1 protease.

Ursolic acid and its malonic acid derivatives can inhibit HIV-1 protease with (IC50) of 8 and 6 μmol/L, respectively.

7. Ursolic acid has anti-diabetic, anti-ulcer

8. Ursolic acid has sedative and sedative effects

Ursolic acid has obvious stabilizing and cooling effects on the central nervous system

9. Ursolic acid can enhance immune function

The production process of ursolic acid powder

After the plants are collected, the raw materials will go through the steps of solvent treatment, extraction, separation and purification, filtration, concentration, purification, and drying to form the final product. Of course, if you have special requirements, we can also design the production process according to your special needs.

How to use ursolic acid powder

You just use our products to formulate yours. It can be mixed directly with your other ingredients to make premixed products. It can also be used directly for filling capsules or making tablets. It also works if your dosage form is a tincture or solution.

Edible method of St. John wort extract powder

We only provide raw materials, you can directly mix with other ingredients to make premix products. It can also be directly used for filling capsules or making tablets as medicine. If your dosage form is tincture or solution, the effect will be better.

Ursolic Acid Powder Extract Supplier

Nutra Herb Components Co., Ltd. has been engaged in plant extraction for more than ten years, with rich experience, meticulous service and trustworthy. If you need ursolic acid powder, you can contact us by email: Sales@nutranerbsource.com.

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