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How much do you know about the application of genistein?

Source:│DateTime:2021-12-20

Genistein (Genistein, Gen) is an active ingredient that is similar in chemical structure to estrogen and is mainly extracted from legumes such as soybeans, clover, and genistein. 


It is called phytoestrogens. A large number of studies have shown that Gen can play a cardiovascular protective role in preventing and treating atherosclerosis (AS), myocardial protection, anti-arrhythmia, and regulating blood pressure by regulating lipid metabolism, anti-oxidation, vascular protection, and anti-inflammatory mechanisms. 


Genistein has the effects of inducing programmed cell death, improving anti-cancer efficacy, and inhibiting angiogenesis. It is a potential cancer chemopreventive agent, and its anti-cancer effect and mechanism have broad application prospects.


Genistein has a wide range of applications, specifically the following applications:

1. Genistein and cardiovascular disease

Genistein plays a very important role in reducing the incidence of cardiovascular diseases. Low-density lipoprotein cholesterol in the blood is high and easily oxidized, which can cause atherosclerosis. Genistein can effectively reduce cholesterol through antioxidant effects, inhibit the oxidation of low-density lipoprotein cholesterol (LDL), and make LDL in the blood. Keep the level low, improve the abnormal peroxidation status in the body caused by high fat, and alleviate the peroxidation damage to the body. 


Genistein can up-regulate LDL receptors, increase LDL receptor activity, and promote cholesterol clearance. Genistein also has the effects of inhibiting the proliferation of smooth muscle cells and angiogenesis, as well as inhibiting cell adhesion, thereby reducing the incidence of cardiovascular diseases.


2. The role of genistein and cranial nerves

The latest literature reports that genistein has the effect of promoting brain nerve regeneration and cerebral coma. Modern medical theory believes that when stroke (cerebral hemorrhage) and stroke (cerebral infarction) occur, a series of pathophysiological changes such as ischemia, hypoxia, degeneration, and necrosis of brain tissue cells are closely related to the influx of calcium ions outside brain tissue cells. 


Relationship: The overload of calcium ions in brain cells is one of the main causes of brain cell degeneration and necrosis. The latest research found that after changing the route of administration, genistein can pass through the blood-brain barrier, and by affecting the Ca++ receptors on brain cell membranes, it can protect brain cells when stroke (cerebral hemorrhage) and stroke (cerebral infarction) occur.

genistein natural sources

3. Genistein and cancer

Genistein inhibits tyrosine kinase activity, inhibits topoisomerase activity, estrogen and anti-estrogen-like effects, and reduces tumor angiogenesis, and has inhibitory and therapeutic effects on various cancers.


4. Genistein and radiation resistance

Genistein (genistein) is an effective inhibitor of protein tyrosine kinase activity. It also has antioxidant and estrogen-like effects. Some people in the United States use genistein to have anti-radiation effects and use it in tumor radiotherapy. 


Side effects prevention and treatment supplies (Bio 300). According to the literature, genistein taking genistein before traumatic brain injury (7.75Gy) can also reduce lung damage in long-term survival animals.


5. Genistein and women's menopausal syndrome

Genistein has weak estrogenic activity and has the effect of estrogen. Studies have shown that women will experience a series of symptoms of menopausal syndrome due to the degeneration of the ovaries and the decrease of estrogen in the body during menopause, and they will take a certain amount of genistein during menopause. 


Supplements the lack of estrogen in the body and plays a role in preventing and reducing women's menopausal syndrome. Experiments suggest that estrogen-like effects may be the main mechanism of genistein to prevent osteoporosis.


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