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Introduction to the knowledge of sialic acid

Source:│DateTime:2021-10-25

Sialic acid structure:

Sialic acid (SA), its scientific name is "N-acetylneuraminic acid". Sialic acid is a natural carbohydrate compound widely found in biological systems. It was first isolated from bovine mandibular salivary gland mucin by Blix. Named sialic acid. 


It is the general name of a family of derivatives with nine-carbon glyconeuraminic acid as the basic structure. There are more than 50 species, which are widely present in cell membrane glycoproteins and lipoproteins in organisms, and play an important role in many important processes of life. , Such as participating in cell recognition, survival, reproduction, biofilm flow, cell endocytosis.


Pure sialic acid is colorless, soluble in water, and does not undergo mutarotation in aqueous solutions. The pure acetoacetone and a light acetoacetone are very stable in aqueous solution and will not change after several months of storage at 4°C. 


If the solvent contains a very small amount of organic acid, its stability will be greatly affected. Diethylphthalide and triethylphthalideneuraminic acid are unstable, and they are easily converted into ethylphthalideneuramic acid at room temperature.


Sialic acid function:

Sialic acid is an essential nutrient for the cognitive development of the human brain. It does not exist in plants. It is abundantly present in vertebrates and higher invertebrates, such as lamb, pork and beef. Eggs are rich in sialic acid, and breast milk contains sialic acid. 


The content is much higher than cow milk, while the content of poultry and fish is very small. Little is known about the mechanism of sialic acid digestion and absorption, and the latest research data only stays on mammals.

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Sialic acid is an important part of brain gangliosides. The content of sialic acid in nerve cell membrane is 20 times that of other cells. Because brain information transmission and nerve impulse transmission must be achieved through synapses, sialic acid is a brain nutrient that acts on brain cell membranes and synapses, so sialic acid can promote The development of memory and intelligence.


Studies have found that increasing the sialic acid content in the breastfeeding diet will increase the sialic acid content in the infant’s brain, and the expression level of genes related to learning will also increase, thereby enhancing their learning and memory capabilities. In infants, the content of sialic acid is only 25% of the content in breast milk. Since sialic acid is synthesized in the liver, in early childhood development, the brain develops very fast, while the liver develops very slowly. It is difficult to synthesize sialic acid by the liver.


To meet the needs of brain development, infants especially need to supplement sialic acid. The babies fed by mothers who eat bird’s nest during lactation are smarter than other babies of the same age. If you don't have bird's nest, you can take some sialic acid supplement, which are also very effective.


If you need sialic acid, you can come to Nutra-Herb Ingredient Inc. to have a look, a professional sialic acid supplier, as well as other animal and plant nutrients for sale~


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