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Aloe extract powder aloin/Diacerein and benefits, uses,side effect, dosage

Aloin, also known as barbaloin, is a bitter, yellow-brown colored compound present in the leaves of Aloe species. Aloin is a commercially important raw drug used worldwide as a laxative and for the treatment of osteroartrits.Commercially aloin is used as a starting compound for the synthesis of aloe-emodin, diacerin and related medicinal compounds.

Product details

Aloe extract powder aloin

Aloin, also known as barbaloin, is a bitter, yellow-brown colored compound present in the leaves of Aloe species. Aloin is a commercially important raw drug used worldwide as a laxative and for the treatment of osteroartrits.Commercially aloin is used as a starting compound for the synthesis of aloe-emodin, diacerin and related medicinal compounds.

 

Aloe


Aloin, also known as barbaloin, is a bitter, yellow-brown colored compound present in the leaves of Aloe species. Aloin is a commercially important raw drug used worldwide as a laxative and for the treatment of osteroartrits.Commercially aloin is used as a starting compound for the synthesis of aloe-emodin, diacerin and related medicinal compounds.


What you may get from us: If you're developing a product that contains plant active ingredients from Aloe species .I think you can find the information or products you need here.


Simple production process in our factory: 

The leaf of Aloe vera when cut from the stem of the plant, a yellow sticky sap, drains out from the bottom of freshly harvested leaf and dried as dark brown coloured lumps. The most important constituents of Aloe bitter leaf sap are the anthrones, aloin A and B and the chromones aloesin and aloeresin A. Aloe bitter sap is homogenously mixed with a solvent. The resultant mixture is centrifuged and concentrated several times to obtain aloin as dry crystalline powder. The powder is further purified to obtain a yellow coloured(Yellow or light yellow) fine powder of Aloin in high purity (about 95%-98%).  

 

How to use Common Aloe extract/Aloin powder:Low content of aloin can be directely used to formulate your products. It can be mixed with your other ingredients directly to make premix products. It can also be directly used for filling capsules or making tablets. High purity of aloin normally used to synthesis Diacerin.

 

Aloe extract/Aloin

Scientifica name

Aloe Vera,Aloe arborescence,or other species.

Appearance

Finepowder

Color

Brown, yellow

Purity of active compunds

2%-98%Aloin

By HPLC or UV

Partical size

Normally pass through 80mesh

Other parameter

We also control other parameters like: moisture, Microbiological limits, Heavy metals.

Pack size

25 kgper paper drum

For pricing or more information, please call 86 29 88444632 or send an email to Sales@nutraherbsource.com


Overview Information

Plant profile:

Common names: 

Aloe vera, Curacao Aloe, Barbados Aloe, Lily of the Desert .aloin, Aloin A, Aloin (Mixture of A and B), Barbalin, Aloin(Barbaloin).


Description: The botanical name of Aloe vera is Aloe barbadensis miller. It belongs to Asphodelaceae (Liliaceae) family, and is a shrubby or arborescent, perennial, xerophytic, succulent, pea- green color plant. It grows mainly in the dry regions of Africa, Asia, Europe and America. In India, it is found in Rajasthan, Andhra Pradesh, Gujarat, Maharashtra and Tamil Nadu.

The plant has triangular, fleshy leaves with serrated edges, yellow tubular flowers and fruits that contain numerous seeds. Each leaf is composed of three layers: 1) An inner clear gel that contains 99% water and rest is made of glucomannans, amino acids, lipids, sterols and vitamins. 2) The middle layer of latex which is the bitter yellow sap and contains anthraquinones and glycosides. 3) The outer thick layer of 15–20 cells called as rind which has protective function and synthesizes carbohydrates and proteins. Inside the rind are vascular bundles responsible for transportation of substances such as water and starch.


Chemical constituents:

Aloin is a constituent of various Aloe species Aloin extracted from natural sources is a mixture of two diastereomers, termed aloin A (also called barbaloin) and aloin B (or isobarbaloin), which have similar chemical properties. Aloin is an anthraquinone glycoside, meaning that itanthraquinone skeleton has been modified by the addition of a sugar molecule. Anthraquinones are a common family of naturally occurring yellow, orange, and red pigments of which many have cathartic properties, attributes shared by aloin. Aloin is related to aloe emodin, which lacks a sugar group but shares aloin's biological properties. Aloin, also known as Barbaloin, is a bitter, yellow-brown colored compound noted in the exudate of at least 68 Aloe species at levels from 0. 1 to 6. 6% of leaf dry weight (making between 3% and 35% of the toal exudate).

Chemical constituents


Thing about Diacerein:

Diacerein, is prescribed for the oral treatment of degenerative joint diseases (osteoarthritis and related diseases). Diacerein is marketed worldwide since September 1994. It is obtained from Aloe Barbadensis and other Aloe species, where Aloin is the starting molecule for the preparation of diacerein. Aloin is initially acetylated, the resultant is deglycosylated to produce  diacerein. The resulting molecule is oxidized and purified resulting in quality diacetylrhein or otherwise named diacerein.

Diacerein [4,5-bis(acetyloxy)-9,10-dihydro-9,10-dioxo-2-anthracene carboxylic acid], a highly purified anthraquinone derivative; is a semi-synthetic pro-drug converted before reaching the systemic circulation to the active metabolite. Based on World Health Organization (WHO) guidelines, diacerein is classified as a symptomatic slow-acting drug in osteoarthritis. According to the European league against rheumatism (EULAR) recommendations for the hip and knee osteoarthritis, diacerein was recommended as a therapeutic option in osteoarthritis with evidence level of 1b.


Potential Health Benefits of AloeExtract,Aloin

Aloin from Aloe vera leaves is a potent anti-influenza compound that inhibits viral neuraminidase activity, even of the oseltamivir-resistant influenza virus. With suppression of this virus machinery, aloin boosts host immunity with augmented hemagglutinin-specific T cell response to the infection. In addition, in the context of compromised benefit with delayed oseltamivir treatment, adjuvant aloin treatment ameliorates the disease and improves survival. Taken together, aloin has the potential to be further evaluated for clinical applications in human influenza.


Uses of Aloin:

As a stimulant-laxative, for the treatment of constipation by inducing bowel movements.

For the production of aloe-emodin, rhein, diacerin and related compounds.


Side effects

Topical: It may cause redness, burning, stinging sensation and rarely generalized dermatitis in sensitive individuals. Allergic reactions are mostly due to anthraquinones, such as aloin and barbaloin. It is best to apply it to a small area first to test for possible allergic reaction.

Oral: Abdominal cramps, diarrhea, red urine, hepatitis, dependency or worsening of constipation. Prolonged use has been reported to increase the risk of colorectal cancer. Laxative effect may cause electrolyte imbalances (low potassium levels).

Contraindication: Contraindicated in cases of known allergy to plants in the Liliaceae family.

Pregnancy and breastfeeding: Oral aloe is not recommended during pregnancy due to theoretical stimulation of uterine contractions, and in breastfeeding mothers, it may sometime causes gastrointestinal distress in the nursing infant.

Interactions: Application of aloe to skin may increase the absorption of steroid creams such as hydrocortisone. It reduces the effectiveness and may increases the adverse effects of digoxin and digitoxin, due to its potassium lowering effect. Combined use of Aloe vera and furosemide may increase the risk of potassium depletion. It decreases the blood sugar levels and thus may interact with oral hypoglycemic drugs and insulin.

 

Dosage:Recommended daily intake not exceeds 14 mg (expressed as barbaloin)


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