What you may get from us: If you're developing a product that contains α-Arbutin.I think you can find the information or products you need here.

Biological production of α-Arbutin from hydroquinone by various microbial enzymes.  

How to use α-Arbutin powder: For cosmetic application.Low content of α-Arbutin can be directely used to formulate face cream and body lotion. It can be mixed with your other ingredients directly to make premix products.

Overview Information

Common names: 

Alpha-arbutin, α-Arbutin, 4-hydroxyphenyl-D-lucopyranoside.

Description: Alpha-Arbutin (4- Hydroxyphenyl-±-D-glucopyranoside) typically activate skin lightness by inhibiting tyrosinase, one of the major enzymes involved in the formation of skin tan and age spots. Alpha-Arbutin reduces the degree of skin tanning after UV exposure and helps to minimize the appearance of liver spots.
Alpha-Arbutin is a pure, water soluble, biosynthetic active ingredient. Alpha-Arbutin blocks epidermal melanin synthesis by inhibiting enzymatic oxidation of Tyrosine and Dopa. It is the more effective, faster and safer approach to promoting skin-brightening and an even skin tone on all skin types.

Mechanism of action/Mechanism of Melanogenesis Inhibition

Alpha-Arbutin has a monophenol moiety,which act as a competing inhibitor in oxidation process of tyrosine by the action of tyrosinase.

The enzyme tyrosinase, one of the key enzymes involved in melanin synthesis, is activated in melanocyte by the stimulation of free radicals induced from UV irradiation and stress. Its activation triggers melanogenesis, a complex series of enzymatic and chemical reactions, and finally leads to the formation of freckles and suntan. The inhibitory effect of α-Arbutin on melanogenesis is thought to be due to direct inhibition of melanosomal tyrosinase activity.

Why Alpha-Arbutin is more effective than beta-Arbutin.

 As shown in Alpha-Arbutin structure, alpha-glucoside bond offers higher efficacy than beta-form. This leads to a better affinity to the active site of tyrosinase than beta-Arbutin. In vitro tests show that inhibitory effect of Alpha-Arbutin on human tyrosinase is estimated to be more than ten times stronger than that of beta-Arbutin. In vivo tests proved Alpha-arbutin is more effective at 1.0% than Beta-Arbutin and 9 times more effective than Beta-Arbutin in vitro. α-Arbutin is a good Melanin production inhibitor.

Benefits ofα-Arbutin :

· Has sun protection properties: α-Arbutin can reduce the degree of skin darkening after sun exposure by blocking the production of tyrosinase.

· Gentle on skin: While other skin brightening agents can dry and irritate skin, arbutin is less irritating.

· Improves uneven complexion: Since α-Arbutin inhibits tyrosinase, an enzyme that helps with melanin production, it can prevent dark spots or even help fade them, leading to a more even complexion.

· Fades dark spots: If you have dark spots from sun exposure or age, arbutin can help fade their appearance.

· Safe to use with other skincare products: There are no known negative interactions between arbutin and other skincare ingredients.

· Safer than hydroquinone: For a while, hydroquinone was the “miracle” skin-lightening ingredient—until it was declared a carcinogenic by the FDA. While hydroquinone works by killing the cells that produce pigmentation and melanin, arbutin inhibits the enzymes that stimulate pigment-producing cells.

· Effective at fading scars: Much like its ability to fade dark spots, arbutin is also great at fading those red-purple acne scars that stick around long after a zit is gone.

Dosage:The Scientific Committee on Consumer safety considers the use of α-Arbutin safe in cosmetic products in a concentration up to 2% in face creams.
The  Scientific Committee on Consumer safety considers the use of α-Arbutin safe in cosmetic products in a concentration up to 0.5% in body lotions.